Targeted contrast agents for MRI of alpha-synuclein deposition

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United States of America Patent

PATENT NO 11779664
APP PUB NO 20220265868A1
SERIAL NO

17737928

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Abstract

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A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I:

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Patent Owner(s)

  • TEXAS CHILDREN'S HOSPITAL; ALZECA BIOSCIENCES, LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Annapragada, Ananth V Manvel, US 12 6
Medici, Carlo Reno, US 7 0
Sun, Xianwei Houston, US 3 0
Tanifum, Eric A Richmond, US 15 11

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