CLEC12AxCD3 bispecific antibodies and methods for the treatment of disease

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United States of America Patent

PATENT NO 11873338
SERIAL NO

17294338

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Abstract

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The disclosure relates to means and methods of treating a subject for a CLEC12A positive cancer. In some embodiments the method comprises treating the subject in need thereof with two or more administrations of a bispecific antibody that binds CD3 and CLEC12A, wherein in a first administration an first amount of the bispecific antibody is administered and wherein in each of the subsequent administrations the amount of bispecific antibody is higher than the amount of bispecific antibody in the first administration. In some embodiments CLEC12A positive cancer treatment methods are provided at intervals and dosing regimens that spare hemopoietic stem cell compartment allowing for recovery of normal CLEC12A positive hemopoietic cells.

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Patent Owner(s)

Patent OwnerAddress
MERUS N VUTRECHT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bakker, Alexander Berthold Hendrik Utrecht, NL 24 406
Bol, Cornelis Jacob Johannes George Utrecht, NL 3 0
Sirulnik, Leonardo Andres Utrecht, NL 3 0
Van, Loo Pieter Fokko Utrecht, NL 13 53
Wasserman, Ernesto Isaac Utrecht, NL 5 0

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