Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof

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United States of America Patent

PATENT NO 11674163
APP PUB NO 20220259627A1
SERIAL NO

17474777

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Abstract

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The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis).

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Patent Owner(s)

  • ARENA PHARMACEUTICALS, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buzard, Daniel J San Diego, US 55 422
DeMattei, John A Berthoud, US 13 93
Gharbaoui, Tawfik Escondido, US 31 289
Johannsen, Stephen R San Diego, US 6 65
Krishnan, Ashwin M San Diego, US 19 415
Kuhlman, Young Mi Plainsboro, US 4 43
Ma, You-An Poway, US 13 134
Martinelli, Michael John San Diego, US 32 199
Montalban, Antonio Garrido San Diego, US 26 192
Sato, Suzanne Michiko San Diego, US 11 129
Sengupta, Dipanjan San Diego, US 40 254

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