Modulators of proteolysis and associated methods of use

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11161841
APP PUB NO 20190315732A1
SERIAL NO

16375643

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present disclosure relates to bifunctional compounds, which find utility as modulators of Kirsten rat sarcoma protein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

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Patent Owner(s)

  • ARVINAS OPERATIONS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crew, Andrew P Guilford, US 82 1383
Dong, Hanqing Madison, US 90 1666
Hornberger, Keith R Southbury, US 33 280
Wang, Jing Milford, US 1507 11315

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