Transgenic T cell and chimeric antigen receptor T cell compositions and related methods

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11377637
APP PUB NO 20190119638A1
SERIAL NO

16091494

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides a T cell wherein one or more therapeutic transgenes is integrated at a within the genome of the cell such that expression of the transgene is under control of an endogenous promoter of the T cell. The invention additional provides methods of making and using such cells to treat a subject with T cell therapy. The invention also provides a T cell wherein a recombinant nucleic acid sequence encoding a chimeric antigen receptor (CAR) is integrated at a first site within the genome of the cell such that the CAR is expressed by the cell at the surface of the cell, and wherein integration of the nucleic acid encoding the CAR at the first site reduces or prevents expression of a functional T cell receptor (TCR) complex at the surface of the cell. The invention additional provides methods of making and using such cells to treat a subject with CAR therapy.

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Patent Owner(s)

  • MEMORIAL SLOAN KETTERING CANCER CENTER

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Eyquem, Justin Gabriel Andre Francois New York, US 2 9
Mansilla-Soto, Jorge Forest Hills, US 7 13
Sadelain, Michel W J New York, US 2 9

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