Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues
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United States of America Patent
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Dec 28, 2010
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Feb 6, 2009
filing date -
Feb 6, 2008
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Abstract
This invention relates to a collagen polypeptide comprising a tripeptide motif having the formula (ProYaaGly).sub.n, where Yaa is an O-methylated amino acid residue and 'n' is the number of motif repeats. Preferred O-methylated amino acid residues at the Yaa position include (2S,4R)-4-methoxyproline. Other suitable amino acid residues at that position include O-mono or O-di-halogenated methylproline. Also, disclosed is a method of making a synthetic or a semi-synthetic collagen polypeptide molecule having increased stability relative to natural collagen. The strengthened collagen molecules are suitable for use in biomaterials for the medical field or in leather-related products prepared by the tanning industry.
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