Methods of predicting responsiveness of a cancer to a VEGF targeting agent and methods of prognosing and treating cancer

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United States of America Patent

PATENT NO 11499973
APP PUB NO 20190204320A1
SERIAL NO

16302343

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Abstract

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Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a VEGF targeting agent are provided. The methods may include obtaining a sample from the subject, determining an expression level of at least one biomarker selected from the group consisting of VEGF-D and PlGF in a sample from the subject, comparing the expression level of the biomarker in the sample to a reference level of the biomarker, and predicting the responsiveness of the cancer to treatment with the cancer therapy including a VEGF targeting agent. Optionally, the methods may further include administering a VEGF target agent and/or an anticancer or chemotherapy agent to the subject. Additional methods of prognosing and treating a cancer in a subject are also provided.

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Patent Owner(s)

  • DUKE UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brady, Chris Durham, US 6 114
Hatch, Ace Durham, US 1 0
Hurwitz, Herbert Durham, US 3 3
Jiang, Chen Durham, US 46 344
Liu, Yingmiao Durham, US 2 0
Nixon, Andrew Durham, US 38 356
Owzar, Kouros Durham, US 6 5
Sibley, Alexander Durham, US 1 0
Starr, Mark Durham, US 1 0

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