Racemization and enantiomer separation of clopidogrel
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United States of America Patent
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Aug 21, 2007
Grant Date -
Mar 3, 2005
app pub date -
Oct 4, 2004
filing date -
Aug 2, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.
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