Synergistic combination of a substance with gastric acid secretion inhibiting effect and an acid degradable antibiotic
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United States of America Patent
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May 13, 1997
Issued Date -
N/A
app pub date -
May 16, 1995
filing date -
Apr 24, 1992
priority date (Note) -
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Abstract
A synergistic pharmaceutical combination and composition are disclosed for the treatment of gastritis and peptic ulcer containing a therapeutic amount of a proton pump inhibitor such as e.g., omeprazole or lansoprazole, which increases intragastric pH, and a therapeutic amount of an acid degradable antibacterial compound such as a penicillin or a macrolide. In particular, the combination is directed to the treatment of infections caused by Helicobacter pylori by raising the bioavailability of acid degradable antibacterial compounds.
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