Single-chain TNF receptor 2 agonist fusion proteins

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United States of America Patent

PATENT NO 11530247
APP PUB NO 20200369739A1
SERIAL NO

16618233

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Abstract

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This invention provides for a fusion protein between a single chain TNFR2 Selective Agonist protein (scTNFR2 Selective Agonist) and a dimerization domain, such as an IgGFc protein. The single chain TNFR2 Selective Agonist moiety provides a therapeutic activity by selectively activating the TNFR2 form of the TNF-α receptor, thus selectively stimulating Tregs and/or increasing myelin deposition.

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Patent Owner(s)

  • RELINIA, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Foster, David C Euless, US 4 32
Giebel, Lutz B San Mateo, US 6 81
Presta, Leonard G San Francisco, US 236 15127

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