9-Thiomaytansinoids and their pharmaceutical compositions and use
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United States of America Patent
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Jan 3, 1984
Grant Date -
N/A
app pub date -
May 3, 1982
filing date -
May 20, 1981
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention relates to 9-thiomaytansinoid compounds represented by the formula ##STR1## wherein R is hydrogen or acyl derived from a carboxylic acid, X is chlorine or hydrogen, Y is hydrogen, lower alkylsulfonyl, or alkyl or aralkyl which are unsubstituted or substituted, and methods of producing the same. The compounds are useful as antitumor, antiprotozoal and antifungal agents.
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