3,6-Disubstituted-5,7-(lower alkano)-5,6,7,8-tetrahydropyrido(4,3-C)pyridazines; their intermediates, preparation, antihypertensive use and compositions
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United States of America Patent
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Jul 7, 1981
Grant Date -
N/A
app pub date -
Oct 26, 1979
filing date -
Nov 10, 1978
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Substituted pyridazines of formula I ##STR1## wherein A denotes a lower alkylene group, R.sup.1 denotes an optionally-substituted or derivatized amino group, R.sup.2 denotes an alkyl group, an alkoxy group, an alkylmercapto group, an optionally-substituted aryl group, a phenalkoxy group or an optionally-substituted amino group and X denotes an oxygen atom or a sulfur atom, and their acid-addition salts with inorganic and organic acids are new compounds. They have an anti-hypertensive effect and are suitable for the treatment of hypertension. Processes for the preparation of the new, pharmacologically-effective compounds, new intermediate products required for their preparation, therapeutic use of the compounds, compositions for such use and unit dosage forms of the compositions are disclosed.
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