Second generation low oxygen affinity pegylated hemoglobins as oxygen-carrying plasma expanders

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United States of America Patent

PATENT NO 8697645
APP PUB NO 20100216695A1
SERIAL NO

12449832

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Abstract

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Provided are hemoglobins having at least two chemical modifications that lower oxygen affinity, hemoglobins chemically modified by the addition of glyceraldehyde-3-phosphate, and hemoglobins having at least two specific chemical modifications. PEGylated versions of these hemoglobins are also provided, as are certain tetraPEGylated and diPEGylated hemoglobins. Methods of modifying a hemoglobin are additionally provided, as are methods of making a hemoglobin. Pharmaceutical compositions and blood substitutes using these hemoglobins are further provided, as are methods of treating a subject using these pharmaceutical compositions and blood substitutes.

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Patent Owner(s)

  • ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Acharya, Seetharama A Cresskill, US 16 116
Manjula, Belur N Cresskill, US 14 192

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