Synthesis of 4-phenylbutyric acid
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United States of America Patent
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Apr 16, 2002
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app pub date -
May 21, 2001
filing date -
May 21, 2001
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Abstract
A method of synthesizing compounds of Formula I: ##STR1## by reacting aromatic compounds with butyrolactone, followed by neutralization with base. The reaction can be conducted in the presence of a catalyst. Preferred catalysts are Lewis acids. A preferred product of Formula I is 4-phenylbutyric acid, which is obtained by the reaction of benzene with butyrolactone in the presence of aluminum chloride, followed by neutralization with base.
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