CLEAVAGE OF VEGF AND VEGF RECEPTOR BY WILDTYPE AND MUTANT MT-SP1

Japan Patent

APP PUB NO JP-2011250789-A
SERIAL NO

2011148609

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Abstract

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PROBLEM TO BE SOLVED: To provide wild type and mutant membrane type serine protease-1 (MT-SP1) polypeptides that cleave VEGF or VEGF receptor, which is known to be involved in angiogenesis.SOLUTION: The invention provides mutant MT-SP1 proteases with altered specificity for target molecules to be cleaved can cleave VEGF or VEGFR at certain substrate sequences with wild-type and mutant MT-SP1 proteases. The invention also provides a method for treating pathologies associated with angiogenesis, such as cancer, using the proteases.

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Patent Owner(s)

Patent OwnerAddress
CATALYST BIOSCIENCES INCNot Provided

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Inventor(s)

Inventor Name Address
NGUYEN JACK -
RUGGLES SANDRA WAUGH -

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