METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS

New Zealand Patent

APP PUB NO NZ-582674-A
SERIAL NO

58267408

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Abstract

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Disclosed is a one pot method for the N-demethylation and N-acylation of a tertiary N-methylated heterocycle comprising reacting an N-methylated heterocycle substrate with an acylating agent reactant selected from the group consisting of an anhydride, a dicarbonate and a dicarbamic anhydride in the presence of a catalyst to obtain an N-acylated derivative product wherein the N-methylated heterocycle is a morphine alkaloid or a derivative thereof.

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UNIV BROCKNot Provided

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Inventor(s)

Inventor Name Address
LEISCH HANNES -
CARROLL ROBERT JAMES -
HUDLICKY TOMAS -
COX D -

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