PROCESS FOR THE PREPARATION OF VORINOSTAT FROM ANILINE, HYDROXYLAMINE AND SUBERIC ACID STARTING MATERIALS

New Zealand Patent

APP PUB NO NZ-592686-A
SERIAL NO

59268609

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Abstract

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Disclosed is a process for the preparation of vorinostat (also known as N-hydroxy-N'-phenyl-octanediamide or suberoylanilide hydroxamic acid (SAHA)), comprising: (a) reacting suberic acid with aniline, or a salt thereof, to form suberanilic acid; and (b) reacting the suberanilic acid formed in step (a) with hydroxylamine, or a salt thereof; or (a') reacting suberic acid with hydroxylamine, or a salt thereof, to form N-hydroxy-7-carboxy-heptanamide; and (b) reacting the N-hydroxy-7-carboxy-heptanamide formed in step (a') with aniline, or a salt thereof; wherein step (a) involves a coupling agent selected from 1,3-dicyclohexylcarbodiimide (DCC); 1,1'-carbonyldiimidazole (CDI); 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (WSC.HC1); 1,3-diisopropylcarbodiimide (DIC); or a mixture thereof; and wherein step (b) involves a coupling agent selected from 1,3-dicyclohexylcarbodiimide (DCC); 1,1'-carbonyldiimidazole (CDI); 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (WSC.HCI); 1,3-diisopropylcarbodiimide (DIC); or a mixture thereof.

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GENERICS UK LTDNot Provided

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Inventor(s)

Inventor Name Address
GORE VINAYAK G -
PATIL MADHUKAR S -
BHALERAO RAHUL A -
MANDE HEMANT M -
MEKDE SANDEEP G -

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