Process for the preparation of febuxostat polymorphs

New Zealand Patent

APP PUB NO NZ-625043-A
SERIAL NO

62504312

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Abstract

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Disclosed is a process for the preparation of Febuxostat (2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid ) form-K comprising: a) dissolving Febuxostat in an ester solvent such as ethyl acetate; b) removing the ester solvent; c) adding a hydrocarbon solvent such as cyclohexane or toluene; and d) isolating Febuxostat crystalline Form-K. Also disclosed is the polymorphic form M1 of Febuxostat. Febuxostat is useful for the treatment of hyperuricemia in patients with gout.

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Patent Owner(s)

Patent OwnerAddress
MYLAN LAB LTDNot Provided

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Inventor(s)

Inventor Name Address
JETTI RAMAKOTESWARA RAO -
BHOGALA BALAKRISHNA REDDY -
BEERAVELLI SATISH -

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