NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF

Philippines Patent

APP PUB NO PH-12016502342-A1
SERIAL NO

12016502342

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Abstract

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Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I) : and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

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Patent Owner(s)

Patent OwnerAddress
SAGE THERAPEUTICS INCUSCAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address
ROBICHAUD ALBERT JEAN BOSTON MA 02110
SALITURO FRANCESCO G 25 BAKER DR MARLBOROUGH MASSACHUSETTS 01752-1374 01752-1374
HARRISON BOYD L PRINCETON JUNCTION NJ 08550
BERESIS RICHARD THOMAS SHANGHAI 200040
BOTELLA GABRIEL MARTINEZ CAMBRIDGE MA 02142

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