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Abstract

Isoquinoline compounds of the following formula are described: ##STR1## wherein the moiety A-B represents a group of formula: --CH.sub.2 --NR.sup.3 -- or --NR.sup.3 --CH.sub.2 --; wherein R.sup.3 represents hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl, optionally substituted benzyl, C.sub.3-6 alkenyl or C.sub.1-4 alkanoyl; wherein R represents hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, or optionally substituted benzyl; wherein R.sup.1 and R.sup.2 each represent hydrogen or taken together represent a chemical bond; and wherein X is hydrogen or halogen; or an acid-addition salt thereof. The compounds are pharmaceuticals and especially useful in the treatment of disorders of the central nervous system.

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First Claim