Synthesis of epothilones, intermediates thereto, analogues and uses thereof
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United States of America Patent
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Dec 7, 2010
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Jan 4, 2007
filing date -
Dec 3, 1996
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Abstract
The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
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