Massively parallel signature sequencing by ligation of encoded adaptors

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United States of America Patent

PATENT NO RE43097
SERIAL NO

12782008

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose protruding strands form perfectly matched duplexes with the complementary protruding strands of the target polynucleotide are ligated, and the identity of the nucleotides in the protruding strands is determined by an oligonucleotide tag carried by the encoded adaptor. Such determination, or “decoding” is carried out by specifically hybridizing a labeled tag complement to its corresponding tag on the ligated adaptor.

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Patent Owner(s)

Patent OwnerAddress
ILLUMINA INC5200 ILLUMINA WAY SAN DIEGO CA 92122 92122

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Albrecht, Glenn Palo Alto, US 12 2316
Brenner, Sydney La Jolla, US 108 21860
DuBridge, Robert B Belmont, US 54 1524
Lloyd, David H Belmont, US 10 631
Pallas, Michael C San Bruno, US 26 3664

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