Vaccines comprising aluminum adjuvants and histidine

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United States of America Patent

PATENT NO RE45587
SERIAL NO

13365202

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Abstract

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To improve the stability of vaccines comprising aluminum salt(s), the invention uses the amino acid histidine. This can improve pH stability and adjuvant adsorption and can reduce antigen hydrolysis. Histidine is preferably present during adsorption to the aluminum salt(s). The antigen in the vaccine may be a protein or a saccharide and is preferably from N. meningitidis.

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Patent Owner(s)

  • GLAXOSMITHKLINE BIOLOGICALS SA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Contorni, Mario Siena, IT 44 395
Maffei, Massimo Siena, IT 4 102

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