APP specific bace inhibitors (ASBIs) and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO RE49873
SERIAL NO

17382969

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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In certain embodiments APP-specific BACE inhibitors (ASBIs) are provided as well as uses thereof. In certain embodiments methods of preventing or delaying the onset of a pre-Alzheimer's condition and/or cognitive dysfunction, and/or ameliorating one or more symptoms of a pre-Alzheimer's condition and/or cognitive dysfunction, or preventing or delaying the progression of a pre-Alzheimer's condition or cognitive dysfunction to Alzheimer's disease are provided where the method involves administering to a subject in need thereof an APP specific BACE inhibitor (ASBI) in an amount sufficient to prevent or delay the onset of a pre-Alzheimer's cognitive dysfunction, and/or to ameliorate one or more symptoms of a pre-Alzheimer's cognitive dysfunction, and/or to prevent or delay the progression of a pre-Alzheimer's cognitive dysfunction to Alzheimer's disease. In certain embodiments the ASBI is a flavonoid (e.g. galangin) or flavonoid prodrug (e.g., galangin prodrug).

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Patent Owner(s)

Patent OwnerAddress
BUCK INSTITUTE FOR RESEARCH ON AGING8001 REDWOOD BLVD NOVATO CA 94945

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bredesen, Dale E Los Angeles, US 48 213
John, Varghese San Francisco, US 153 1160

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