AFFINITY-MATURED HUMANIZED ANTI CEA MONOCLONAL ANTIBODIES

Singapore Patent

APP PUB NO SG-178567-A1
SERIAL NO

2012013306

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Abstract

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The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies or variants thereof specific for cell surface or membrane bound human CEA. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.

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Patent Owner(s)

Patent OwnerAddress
ROCHE GLYCART AGCHWAGISTRASSE 18 SCHLIEREN-ZÜRICH CH-8952

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Inventor(s)

Inventor Name Address
MOESSNER EKKEHARD SCHLIEREN
UMANA PABLO ZURICH
HOSSE RALF CHAM
HOFER THOMAS U ZURICH

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