Antibody conjugates and methods of making and using the same

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11208632
APP PUB NO 20170306300A1
SERIAL NO

15495431

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Abstract

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Antibodies that include a sulfatase motif-containing tag in a constant region of an immunoglobulin (Ig) light chain polypeptide are disclosed. The sulfatase motif can be converted by a formylglycine-generating enzyme (FGE) to produce a formylglycine (fGly)-modified Ig light chain polypeptide. An fGly-modified Ig light chain polypeptide of the antibody can be covalently and site-specifically bound to a moiety of interest to provide an antibody conjugate. The disclosure also encompasses methods of production of such tagged Ig light chain polypeptides, fGly-modified Ig light chain polypeptides, and antibody conjugates, as well as methods of use of same.

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Patent Owner(s)

Patent OwnerAddress
R P SCHERER TECHNOLOGIES LLC112 NORTH CURRY STREET CARSON CITY NV 89703

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Chao Bai San Leandro, US 11 105
Kim, Yun Cheol Walnut Creek, US 13 3
Rabuka, David Kensington, US 57 343

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