Process for preparation of propionic acid derivatives
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United States of America Patent
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Jan 16, 2001
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N/A
app pub date -
Mar 16, 1999
filing date -
Mar 24, 1998
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Abstract
(R)(+)-2-[4-(5-chloro 3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid propinyl ester is produced by converting a compound of formula II ##STR1## in an inert organic solvent, without isolation of the intermediate products, with M.sub.2 CO.sub.3, in which M is sodium or potassium, into the compound of formula III ##STR2## reacting this with the compound of formula IV ##STR3## to form the compound of formula V ##STR4## and converting this with a compound of formula VI ##STR5## wherein Z signifies phenylsulphonyl, tosyl, methylsulphonyl, nosyl, bromophenyl, Cl-, Br- or CICO-, into the compound of formula I.
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