Process for preparing water soluble diterpenes and their applications
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United States of America Patent
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Nov 1, 2005
Grant Date -
Mar 10, 2005
app pub date -
Sep 8, 2003
filing date -
Sep 8, 2003
priority date (Note) -
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Abstract
Aqueous solutions of diterpenes such as Forskolin, its congeners, analogs and derivatives, up to approximately 6% concentration, are prepared using suitably substituted cyclodextrin as a solubilizing agents. In the absence of cyclodextrin, some diterpenes such as Forskolin are soluble in water only to concentrations of about 0.001%. Such aqueous solutions find applications in topical and systemic use, as pharmaceutical, cosmeceutical, nutraceutical preparations containing diterpenes such as Forskolin and congeners.
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