Core 2 GlcNAc-T inhibitors
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United States of America Patent
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Mar 15, 2011
Grant Date -
Dec 25, 2008
app pub date -
Dec 22, 2004
filing date -
Dec 22, 2003
priority date (Note) -
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Abstract
Method of treating conditions associated with raised activity of core 2 GlcNAc-T by administering an inhibitor of UDP-GlcNAc:Galβ1,3GalNAc-R (GlcNAc to GalNAc) β1,6-N-acetylglucosaminyl transferase (core 2 β1,6 N-acetylaminotransferase, core 2 GlcNAc-T-EC 2.4.1.102). Diseases associated with raised activity of core 2 GlcNAc-T include inflammatory diseases, atherosclerosis, diabetic cardiomyopathy, cancers, including treatment or prevention of metastasis, or diabetic retinopathy.
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