Methods for the manufacture of pure single enantiomer compounds and for selecting enantioselective enzymes
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United States of America Patent
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Jul 19, 2011
Grant Date -
May 15, 2003
app pub date -
Jun 21, 2002
filing date -
Jun 21, 2001
priority date (Note) -
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Abstract
The invention provides biocatalytic methods for the manufacture of pure single enantiomer compounds. This invention provides methods of screening for enzymes which are highly enantioselective or enzymes that can provide any desired stereoisomer of a compound. The invention provides the use of single enantiomer substrates in performing a growth screen of a clonal library to identify highly stereoselective enzymes. In one aspect, methods for screening and identification of enzymes, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases are provided. Methods for the production and screening of gene libraries generated from nucleic acids isolated from more than one organism for enzyme, e.g., transaminase, activities are also provided.
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