Genetically engineered swine influenza virus and uses thereof
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United States of America Patent
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Feb 28, 2012
Grant Date -
Jan 8, 2009
app pub date -
Jun 1, 2005
filing date -
Jun 1, 2004
priority date (Note) -
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Abstract
The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated swine influenza viruses having modifications to a swine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.
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