INHIBITORS OF RECEPTOR ACTIVATOR OF NF-κB AND USES THEREOF

World Intellectual Property Organization Patent

APP PUB NO WO-2002092623-A1
SERIAL NO

PCTUS0214842

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The present invention provides a RANK (receptor activator of NF-κB) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiation, thus indicating that targeted disruption of interaction between RANK and TRAF6 may prove useful as a therapeutic for metabolic bone disorders, leukemia, arthritis, and metastatic cancer of the bone.

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