PRODUCTION OF FUNCTIONAL ANTIBODIES IN FILAMENTOUS FUNGI

World Intellectual Property Organization Patent

APP PUB NO WO-2003089614-A2
SERIAL NO

PCTUS0312246

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Described herein are methods for the production of monoclonal antibodies in filamentous fungi host cells. The monoclonal antibodies are expressed as full-length fusion proteins that retain functional antigen binding and antibody-dependent cellular cytotoxicity capabilities. Improvements in the cleavage of the glucoamylase-light chainfusion protein to yield a mature antibody are also provided. The antibodies produced in filamentous fungi show equivalent pharmacokinetic disposition to antibodies produced in mammalian cells.

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