COMPOSITIONS AND METHODS FOR COMBINATION ANTIVIRAL THERAPY

World Intellectual Property Organization Patent

APP PUB NO WO-2004064846-A1
SERIAL NO

PCTUS2004000868

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Abstract

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The present invention relates to therapeutic combinations of [9-[R-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine(GS-7340) and (2R, 5S, cis)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (emtricitabine,(-)-cis FTC, EmtrivaTM and their physiologically functional derivatives. The combinations may be useful in the treatment of HIV infections, including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors. The present invention is also concerned with pharmaceutical compositions and formulations of said combinations of GS-7340 and emtricitabine, and their physiologically functional derivatives, as well as therapeutic methods of use of those compositions and formulations.

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Patent Owner(s)

Patent OwnerAddress
GILEAD SCIENCES INCUSFOSTER CITY CALIFORNIA 94404

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Inventor(s)

Inventor Name Address
DAHL TERRENCE C SUNNYVALE CA
MENNING MARK M FOSTER CITY CA
OLIYAI REZA BURLINGAME CA

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