COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS

World Intellectual Property Organization Patent

APP PUB NO WO-2006009869-A1
SERIAL NO

PCTUS2005021524

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Abstract

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One aspect of the present invention relates to isoxazoline derivatives that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising an isoxazoline derivative of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.

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Patent Owner(s)

Patent OwnerAddress
INFINITY PHARMACEUTICALS INCUSCAMBRIDGE MA 02139

International Classification(s)

Inventor(s)

Inventor Name Address
CASTRO ALFREDO C SOMERVILLE MA
FOLEY MICHAEL A NEW YORK NY
YU LIN-CHEN QUINCY MA
GROGAN MICHAEL J WINCHESTER MA
LIU TAO U S A
MANN DAVID A SARASOTA FL
UNDERWOOD DENNIS J JAMAICA PLAIN MA
DENG WEI SAN DIEGO CA
GEORGES EVANGELINOS ASIMINA T MASSACHUSETTS MASSACHUSETTS
DEPEW KRISTOPHER M ACTON MA
FRITZ CHRISTIAN C NATICK MA 01760
HAFEEZ NAFEEZA CAMBRIDGE MASSACHUSETTS 02139
HOLSON EDWARD B NEWTON HIGHLANDS MA
KONEY NII O NEW YORK NY
HOPKINS BRIAN T CAMBRIDGE MA 02142
WYLIE ANDREW A BROOKLINE MA 02446
SNYDER DANIEL A MANCHESTER CT CONNECTICUT 06040
MARCAURELLE LISA A ARLINGTON MA
ZHANG LINPING LEXINGTON MA

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