METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS

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Jan 8, 2009
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Jun 30, 2008
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Jun 29, 2007

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Abstract

The present invention relates to a one-pot method for N-demethylation and/or N-acylation of a tertiary N-methylated heterocycle such as morphine alkaloids or tropane alkaloids The method, exemplified by Scheme 1, comprises reacting said tertiary N-methylated heterocycle with an acylatmg agent in the presence of a Pd metal catalyst.

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UNIV BROCK	CA

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C07D:HETEROCYCLIC COMPOUNDS

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Inventor Name	Address
HUDLICKY TOMAS	ST CATHARINES
LEISCH HANNES	ST CATHARINES
CARROLL ROBERT JAMES	ST CATHARINES
COX D PHILLIP	AUDUBON PA

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2009003270

METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS

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METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS

World Intellectual Property Organization Patent

PCTCA2008001177

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APP PUB NO	WO-2009003270-A1
SERIAL NO	PCTCA2008001177
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PCTCA2008001177

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