TUBULAR NANOSTRUCTURE TARGETED TO CELL MEMBRANE

World Intellectual Property Organization Patent

APP PUB NO WO-2010030381-A1
SERIAL NO

PCTUS2009005111

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Abstract

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Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.

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Patent Owner(s)

Patent OwnerAddress
SEARETE LLCUSBELLEVUE WA 98005-4046

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Inventor(s)

Inventor Name Address
MYHRVOLD NATHAN P BELLEVUE WA
WOOD LOWELL L JR 989 112TH AVENUE NE #2310 BELLEVUE WASHINGTON 98004 98004
HYDE RODERICK A REDMOND WA
KARE JORDIN T SAN JOSE CA
HARLOW ED BOSTON MA
TEGREENE CLARENCE T BELLEVUE WA
LEUTHARDT ERIC C ST LOUIS MO
ISHIKAWA MURIEL Y LIVERMORE CA
JUNG EDWARD K Y BELLEVUE WA
SWEENEY ELIZABETH A SEATTLE WA
WOOD VICTORIA Y H LIVERMORE CA
BANGERA MAHALAXMI GITA RENTON WA
RIVET DENNIS J RICHMOND VA

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