PROTEIN SECRETION

World Intellectual Property Organization Patent

APP PUB NO WO-2012110821-A1
SERIAL NO

PCTGB2012050352

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Abstract

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A bacterial expression construct comprises a nucleic acid sequence encoding a secretion unit peptide comprising less than 300 amino acids of the C-terminus of a SPATE-class bacterial autotransporter polypeptide, the secretion unit peptide 5 comprising: (i) the α-helix; (ii) linker; and (iii) β-barrel region of the β-domain of the autotransporter polypeptide. Such an expression construct, and associated nucleic acids and peptides, find application in the expression of proteins of interest from a host bacterial cell to the cell culture medium.

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Patent Owner(s)

Patent OwnerAddress
UNIV BIRMINGHAMGB

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Inventor(s)

Inventor Name Address
SEVASTSYANOVICH YANINA ROMANOVNA BIRMINGHAM WEST MIDLANDS B15 2TT
LEYTON DENISSE BIRMINGHAM WEST MIDLANDS B15 2TT
HENDERSON IAN ROBERT BIRMINGHAM WEST MIDLANDS B15 2TT

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