PROTEIN-POLYMER-DRUG CONJUGATES

World Intellectual Property Organization Patent

APP PUB NO WO-2012171020-A1
SERIAL NO

PCTUS2012041931

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Abstract

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A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by Lp. Each occurrence of D is independently a therapeutic agent having a molecular weight ≤ 5 kDa. LD and Lp are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

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Patent Owner(s)

Patent OwnerAddress
MERSANA THERAPEUTICS INCUS840 MEMORIAL DRIVE CAMBRIDGE MASSACHUSETTS 02139 02139

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Inventor(s)

Inventor Name Address
BODYAK NATALYA D BROOKLINE MA 02446
LOWINGER TIMOTHY B CARLISLE MA
HAMMOND CHARLES E 4 CHESTER AVENUE BURLINGTON MA 01803
YURKOVETSKIY ALEKSANDR LITTLETON MASSACHUSETTS 01460
STEVENSON CHERI A HAVERHILL MA
GUMEROV DMITRY R WALTHAM MA 02451
THOMAS JOSHUA D NATICK MA
YIN MAO NEEDHAM MA
CONLON PATRICK R WAKEFIELD MA

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