PROTEIN VARIANT GENERATION BY REGION SHUFFLING

World Intellectual Property Organization Patent

APP PUB NO WO-2013003290-A1
SERIAL NO

PCTUS2012044070

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Abstract

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Region shuffling methods for efficiently introducing diversity and exploring sequence space are described. Libraries produced directly from these methods contain high fractions of protein variants harboring multiple beneficial mutations. Typically, the methods produce these variants efficiently without the need for sequencing beneficial mutants identified at intermediate stages of the process.

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Patent Owner(s)

Patent OwnerAddress
CODEXIS INCUSREDWOOD CITY CA 94063

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Inventor(s)

Inventor Name Address
CLARK LOUIS REDWOOD CITY CALIFORNIA 94063
CHOUDHARY TRISH REDWOOD CITY CA 94063

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