UBIQUITIN CHAIN ASSEMBLY

World Intellectual Property Organization Patent

APP PUB NO WO-2013041242-A1
SERIAL NO

PCTEP2012003988

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Abstract

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There is provided a method for producing free polyubiquitin chains linked through a single desired lysine residue, comprising the steps of: (a) selecting an E3 ubiquitin ligase enzyme which is homologous to mammalian HECT E3 ligases and possesses the desired lysine residue specificity; (b) incubating the E3 enzyme with an E1 ubiquitin activating enzyme, an E2 ubiquitin conjugating enzyme and monomeric ubiquitin; and (c) if undesired linkages are present, removing the undesired linkages by exposure to a DUB enzyme having the appropriate specificity.

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Patent Owner(s)

Patent OwnerAddress
MEDICAL RES COUNCILGBLONDON

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Inventor(s)

Inventor Name Address
KOMANDER DAVID CAMBRIDGE
HOSPENTHAL MANUELA K CAMBRIDGE

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