INHIBITION OF VIRAL GENE EXPRESSION

World Intellectual Property Organization Patent

APP PUB NO WO-2013061295-A1
SERIAL NO

PCTIB2012055915

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Abstract

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This invention relates to modified short interfering RNA (siRNA) nucleic acid molecules, particularly siRNA's which have been modified by the addition of a 2 -0- guanidinopropyl (GP) modified nucleoside. In particular the invention relates to modified siRNAs which are capable of silencing target sequences, methods of treating and preventing infection by using the siRNAs, medicaments containing the siRNAs and use of the siRNAs.

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Patent Owner(s)

Patent OwnerAddress
UNIV WITWATERSRAND JHBZA

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Inventor(s)

Inventor Name Address
ARBUTHNOT PATRICK 1 JAN SMUTS AVENUE 2050 JOHANNESBURG 2050
BERNHARDT STEFAN OFFENBACH-RUMPENHEIM
HEAN JUSTIN 2050 JOHANNESBURG
ELY ABDULLAH 1 JAN SMUTS AVENUE 2050 JOHANNESBURG 2050
MARIMANI MUSA 2050 JOHANNESBURG
BRZEZINSKA JOLANTA 60438 FRANKFURT AM MAIN
D ONOFRIO JENNIFER 60438 FRANKFURT AM MAIN
BUFF MAXIMILIAN C R 60438 FRANKFURT AM MAIN
ENGELS JOACHIM W 60438 FRANKFURT AM MAIN

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