COMBINATION THERAPIES COMPRISING ANTI-ERBB3 AGENTS

World Intellectual Property Organization Patent

APP PUB NO WO-2014036520-A1
SERIAL NO

PCTUS2013057714

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Abstract

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Disclosed are methods and compositions for inhibiting the growth of a tumor (e.g., a malignant 5 tumor) in a subject. In particular, combination therapies for treating a tumor in a subject by coadministering an agent selected from i) an effective amount of an anti-estrogen agent; ii) an effective amount of a receptor tyrosine kinase inhibitor; iii) an effective amount of a MEK/PI3 kinase/ AKT inhibitor; iv) an effective amount of MM-151; v) an effective amount of an mTOR inhibitor; and/or vi) an effective amount of trastuzumab or T-DM 1, and/or combinations thereof; and an effective amount of a 10 bispecific anti-ErbB2/anti-ErbB3 antibody.

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Patent Owner(s)

Patent OwnerAddress
MERRIMACK PHARMACEUTICALS INCUSCAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address
ZHANG BO BALDWIN PARK CA 91706
MCDONAGH CHARLOTTE CAMBRIDGE MASSACHUSETTS 02142
HUHALOV ALEXANDRA LEXINGTON MA 02420-3708

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