ANTIBODY-DRUG CONJUGATE PRODUCED BY BINDING THROUGH LINKER HAVING HYDROPHILIC STRUCTURE

World Intellectual Property Organization Patent

APP PUB NO WO-2014061277-A1
SERIAL NO

PCTJP2013006178

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Abstract

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Provided is an antibody-drug conjugate which can be used as an anti-tumor agent having an excellent anti-tumor effect and high safety, said conjugate being characterized in that an anti-tumor compound represented by formula (1) is bound to an antibody through a linker having a structure represented by the formula: -L1-L2-LP-NH-(CH2)n1-La-Lb-Lc- or the formula: -L1-L2-LP- (wherein the antibody is bound at the terminal of L1, the anti-tumor compound is bound at the terminal of Lc or LP, and a hydrophilic structure is contained in at least one selected from L1, L2 and LP).

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Patent Owner(s)

Patent OwnerAddress
DAIICHI SANKYO CO LTDJPTOKYO JAPAN TOKYO METROPOLIS

International Classification(s)

Inventor(s)

Inventor Name Address
MASUDA TAKESHI TOKYO 103-8426
ASHIDA SHINJI TOKYO
YOSHIDA MASAO KANAGAWA
NAITO HIROYUKI TOKYO 143-8555
MIYAZAKI HIDEKI HITACHI
ABE YUKI TOKYO 130-8603
KASUYA YUJI SHINAGAWA-KU TOKYO 140-8710
NAKADA TAKASHI TOKYO
OGITANI YUSUKE TOKYO

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