MONOCLONAL ANTIBODIES AGAISNT ACTIVATED PROTEIN C (aPC)
World Intellectual Property Organization Patent
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Abstract
Provided herein are antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human activated Protein C (aPC) with minimal binding to its zymogen Protein C (PC). Moreover, these aPC binding proteins could potentially block the anti-coagulant activity of aPC to induce coagulation. Therapeutic uses of these binders are described herein as are methods of panning and screening specific antibodies.
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
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Patent Owner(s)
| Patent Owner | Address |
|---|---|
| BAYER HEALTHCARE LLC | USNEW JERSEY NEW JERSEY |
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Inventor(s)
| Inventor Name | Address |
|---|---|
| WILMEN ANDREAS | ARNDTSTR 5 50676 KÖLN |
| MURPHY JOHN E | BERKELEY CALIFORNIA 94707 |
| WANG ZHUOZHI | MILLBRAE CALIFORNIA 94030 |
| GU JIAN-MING | LAFAYETTE CA |
| MCLEAN KIRK | FULLERTON CA |
| BAUZON MAXINE | HERCULES CALIFORNIA 94547 |
| MARQUARDT TOBIAS | WUPPERTAL |
| KIM JI-YUN | BERKELEY CA |
| ZHAO XIAO-YAN | UNION CITY CA |
| JIN FANG | C/O PFIZER INC 610 MAIN STREET CAMBRIDGE MASSACHUSETTS 02139 02139 |
| WANG XINQUAN | 310003 THREE UNITS 1901 WANDA COMMERCIAL CENTER GONGSHU DISTRICT HANGZHOU CITY ZHEJIANG PROVINCE HANGZHOU CITY ZHEJIANG PROVINCE 310003 |
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