CRYSTALLINE FORMS OF A MACROCYCLIC HCV NS3 INHIBITING TRIPEPTIDE

World Intellectual Property Organization Patent

APP PUB NO WO-2015100144-A1
SERIAL NO

PCTUS2014071310

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Abstract

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Crystalline forms of the anti-HCV compound (1R,5S,8S,9S,10R,22aR )-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6] dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state. Also provided are processes of manufacture and methods of using the crystalline forms.

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Patent Owner(s)

Patent OwnerAddress
GILEAD SCIENCES INCUSFOSTER CITY CA 94404

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Inventor(s)

Inventor Name Address
MORRISON HENRY DUBLIN CA
LAPINA OLGA FOSTER CITY CALIFORNIA 94404
FUNG PETER SUNNYVALE CA 94086
CHAN JOHANN FOSTER CITY CALIFORNIA 94404
PCION DOMINIKA FOSTER CITY CALIFORNIA 94404
BRINGLEY DUSTIN FOSTER CITY CALIFORNIA 94404
KEATON KATIE FOSTER CITY CALIFORNIA 94404

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