METHOD FOR SYNTHESIZING 25-HYDROXY CHOLESTEROL
World Intellectual Property Organization Patent
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Abstract
Disclosed is a method for synthesizing 25-hydroxy cholesterol. The method is as below: subjecting 24-dehydrocholesterol derivative as a raw material and a hydroxyl containing reagent to an addition reaction in the presence of a catalyst in an organic solvent, hydrolyzing the reaction product and separating to obtain 25-hydroxy cholesterol. The present invention adopts hydroxyl containing reagents such as water, formic acid, acetic acid, propionic acid, butyric acid, benzoic acid , p-methyl benzoic acid and etc. to replace the commonly used extremely toxic reagents such as Cr reagent, Hg reagent , multi-fluorinated acetone and etc. in the prior art. The raw materials of the present invention are easily available, and have low effect on environment. The operation and post treatment are convenient. Moreover, the method has the advantages of mild reaction conditions, simple operation, good selectivity, high efficiency, high yield, simple post-treatment, easy product separation, less three wastes and easy industrialization.
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