ANTIBODY CONJUGATES AND METHODS OF MAKING AND USING THE SAME

World Intellectual Property Organization Patent

APP PUB NO WO-2017189432-A1
SERIAL NO

PCTUS2017029142

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Abstract

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Antibodies that include a sulfatase motif-containing tag in a constant region of an immunoglobulin (Ig) light chain polypeptide are disclosed. The sulfatase motif can be converted by a formylglycine-generating enzyme (FGE) to produce a formylglycine (fGly)-modified Ig light chain polypeptide. An fGly-modified Ig light chain polypeptide of the antibody can be covalently and site- specifically bound to a moiety of interest to provide an antibody conjugate. The disclosure also encompasses methods of production of such tagged Ig light chain polypeptides, fGly-modified Ig light chain polypeptides, and antibody conjugates, as well as methods of use of same.

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Patent Owner(s)

Patent OwnerAddress
SCHERER TECHNOLOGIES LLC R PUS

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Inventor(s)

Inventor Name Address
RABUKA DAVID 202 STANFORD AVENUE KENSINGTON CALIFORNIA 94708 94708
HUANG CHAO BAI SAN LEANDRO CA
KIM YUN CHEOL 460 GENTRY CT WALNUT CREEK CALIFORNIA 94598 94598

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