REAGENTS AND METHODS FOR ALIPHATIC CARBON—HYDROGEN BOND FUNCTIONALIZATION

World Intellectual Property Organization Patent

APP PUB NO WO-2022241129-A1
SERIAL NO

PCTUS2022029013

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Abstract

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The subject matter contained herein relates generally to methods and compounds that facilitate aliphatic carbon-hydrogen bond functionalization by group transfer via a nitrogen-centered radical in the presence of a trap, and the functionalized compounds prepared therefrom. The subject matter described herein provides a platform and the ability to efficiently and selectively introduce a range of valuable functionality on diverse hydrocarbon substrates ranging from methane to polyolefins with >3500 carbon atoms. As described herein, the reagents employed can form reactive N-centered radicals, the kinetics of which do not compete with companion radical traps. This technology finds usefulness in enhancing capabilities in late-stage diversification, while the molecules and materials now made accessible can provide solutions to important challenges in medicinal chemistry and materials science.

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Patent Owner(s)

Patent OwnerAddress
UNIV NORTH CAROLINA CHAPEL HILLUS

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Inventor(s)

Inventor Name Address
ALEXANIAN ERIK 108 DAIRY COURT CHAPEL HILL NC 27516 27516
LEIBFARTH FRANK CARRBORO NC
ALTY JILL CHAPEL HILL NC
FAZEKAS TIMOTHY CHAPEL HILL NC

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