PRODUCTION OF ALPHA-1,3-FUCOSYLATED COMPOUNDS

World Intellectual Property Organization Patent

APP PUB NO WO-2023110995-A1
SERIAL NO

PCTEP2022085811

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Abstract

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The present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. The present invention describes methods for the production of a fucosylated compound using a fucosyltransferase as well as the purification of said fucosylated compound, said fucosyltransferase having alpha-1,3-fucosyltransferase activity on the N-acetylglucosamine (GlcNAc) and/or the glucose (Glc) residue of Gal-β1,m-GlcNAc-β1,n-Gal-β1,4-Glc of a saccharide substrate comprising Gal-β1,m-GlcNAc- β1,n-Gal-β1,4-Glc wherein said m is 3 or 4 and said n is 3 or 6. The present invention also provides a cell for production of a fucosylated compound. Next, the present invention describes methods for the production of 3-fucosyllactose (3-FL) using a fucosyltransferase having alpha-1,3-fucosyltransferase activity on the Glc residue of lactose, as well as the purification of said 3-FL. The present invention also provides a cell for production of 3-FL.

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Patent Owner(s)

Patent OwnerAddress
INBIOSE NVBE

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Inventor(s)

Inventor Name Address
BEAUPREZ JOERI C/O INBIOSE N V TECHNOLOGIEPARK 82 BUS 41 9052 ZWIJNAARDE 9052
VANDEWALLE KRISTOF TECHNOLOGIEPARK 82 BUS 41 9052 ZWIJNAARDE 9052
VERCAUTEREN ANNELIES ZWIJNAARDE

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